Qubo launched on September 9, 2006, with the premiere of weekend morning blocks on NBC (which aired exclusively on Saturday mornings, replacing Discovery Kids on NBC, a weekly block programmed by the Discovery Kids cable network; renamed The Hub in 2010 and Discovery Family in 2014) and Telemundo (which aired on both Saturday and Sunday mornings); that was followed on September 15 by the introduction of a daytime block on i: Independent Television (now Ion Television), which initially aired on Friday afternoons. At launch, its programming included the first-run animated series Dragon (distributed by Scholastic) and Jane and the Dragon (produced by Corus subsidiary Nelvana), along with VeggieTales and its spinoffs 3-2-1 Penguins! and Larryboy: The Cartoon Adventures (produced by DreamWorks Classics subsidiary Big Idea, itself now a part of NBCUniversal) – marking the first time that VeggieTales had ever been broadcast as a television program.

With the acquisition of NBCUniversal by Comcast, it was announced on March 28, 2012, that NBC and Telemundo would discontinue their Qubo blocks and replace them with NBC Kids and MiTelemundo –2 separate weekend morning preschool programming blocks which would both be programmed by PBS Kids Sprout, a preschool-oriented television network that came under NBC ownership as part of the merger – on July 7; leaving Ion Television as the only remaining network with a Qubo-branded programming block (with Ion Media acquiring NBCUniversal's interest in the venture). At the time, PBS Kids Sprout was a competing joint venture between Comcast, HIT Entertainment, PBS and Sesame Workshop; NBCUniversal acquired full ownership of the cable network in November 2013, and PBS Kids Sprout suddenly became simply Sprout as a result (though it would later become Universal Kids less than four years later as a result of purchasing DreamWorks Animation). Ion Media Networks acquired the stakes in Qubo held by DreamWorks Classics (which acquired Classic Media in 2012; itself now a part of NBCUniversal), Scholastic and Corus Entertainment in 2013, with all three companies retaining program distribution partnerships with the network. The Qubo block on Ion Television was renamed as the "Qubo Kids Corner" on January 4, 2015, concurrent with the block's move from Friday to Sunday mornings. Now, it's a 3-hour block that airs on Fridays from 8-11AM.

Former Programming